IF 52.7 | 云克隆GABA小分子檢測(cè)試劑盒揭示內(nèi)皮GABA抗主動(dòng)脈夾層的作用機(jī)制
2026年4月24日，蘇州大學(xué)附屬第一醫(yī)院沈振亞教授團(tuán)隊(duì)在《Signal Transduction and Targeted Therapy》上發(fā)表了題為：Endothelial GABA protects against aortic dissection by inhibiting endothelial and mitochondrial dysfunction and maintaining vascular homeostasis的研究論文。該研究揭示了內(nèi)皮細(xì)胞γ-氨基丁酸（GABA）通過(guò)抑制內(nèi)皮功能障礙與線粒體損傷、維持血管內(nèi)環(huán)境穩(wěn)態(tài)，從而抵御主動(dòng)脈夾層發(fā)生發(fā)展的全新保護(hù)機(jī)制，為主動(dòng)脈夾層的發(fā)病機(jī)制解析、早期診斷及靶向防治提供了全新的理論依據(jù)與潛在干預(yù)靶點(diǎn)。
產(chǎn)品名稱(chēng)：γ-氨基丁酸(gABA)檢測(cè)試劑盒(酶聯(lián)免疫吸附試驗(yàn)法) 產(chǎn)品編號(hào)：CEA900Ge
Fig. 2 f Dot plot of the GABA concentration in the control and TAD groups (t test, mean ± S.D.; P value = 0.0041) . g ELISA was used to determine the concentration of GABA in the intima (t test, mean ± S.D.) .
Fig. 4 Clinical signi?cance of plasma GABA levels in thoracic aortic dissection.
a The expression level of GABA in the plasma of TAD patients(n = 90) and healthy controls (n = 50) (t test, mean ± S.D.) .
c The expression level of plasma GABA in the healthy control group compared with the Stanford A and Stanford B groups (one-way ANOVA, mean ± S.D.) .
e Prespeci?c analysis of the risk of TAD events according to different GABA level groups (95% CIs) .
f Proportion of samples distributed in groups with different GABA concentrations.
g Correlation analysis of the plasma GABA concentration and PREVENT risk score with the occurrence of TAD.
針對(duì)GABA靶標(biāo)，云克隆不僅提供高靈敏的ELISA檢測(cè)試劑盒，還配套開(kāi)發(fā)有重組蛋白、特異性抗體及多因子檢測(cè)試劑盒等全系列產(chǎn)品，為心血管疾病相關(guān)研究提供一站式科研解決方案。
